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. Author manuscript; available in PMC: 2012 Feb 1.

Published in final edited form as: Vaccine. 2010 Dec 16;29(6):1201–1210. doi: 10.1016/j.vaccine.2010.12.004

Tornado Diagrams a) School-age Children and b) women of reproductive age. The central axis represents the resulting ICER when all parameters listed were set to their midpoint value of their explored ranges: infection risk (range: 25% – 100% of age-specific probability), drug cure rate (range: 50% – 100% of baseline distribution), drug egg reduction (range: 50% – 100% of baseline distribution), vaccine cost (range: $1 – $100), vaccine efficacy in preventing infection (range: 30 – 60%) vaccine efficacy in reducing egg production (range: 40 – 80%), drug and delivery costs (range: 50% – 150% of age-specific costs). Table 1 shows baseline values for each parameter. The dashed vertical line marks where the ICER = 0. Negative ICERs occur when adding vaccination to drug treatment economically dominates drug treatment alone.

Tornado Diagrams a) School-age Children and b) women of reproductive age. The central axis represents the resulting ICER when all parameters listed were set to their midpoint value of their explored ranges: infection risk (range: 25% – 100% of age-specific probability), drug cure rate (range: 50% – 100% of baseline distribution), drug egg reduction (range: 50% – 100% of baseline distribution), vaccine cost (range: $1 – $100), vaccine efficacy in preventing infection (range: 30 – 60%) vaccine efficacy in reducing egg production (range: 40 – 80%), drug and delivery costs (range: 50% – 150% of age-specific costs). Table 1 shows baseline values for each parameter. The dashed vertical line marks where the ICER = 0. Negative ICERs occur when adding vaccination to drug treatment economically dominates drug treatment alone.