Table 1.

Characteristics and course of anthracycline-induced cardiotoxicity [15].

Characteristics	Acute cardiotoxicity	Early-onset, chronic progressive cardiotoxicity	Late-onset, chronic progressive cardiotoxicity
Onset	Within the first week of anthracycline treatment	<1 year after the completion of anthracycline treatment	≥1 year after the completion of anthracycline treatment
Risk factor dependence	Unknown	Yesa	Yesa
Clinical features in adults	Transient depression of myocardial contractility	Dilated cardiomyopathy	Dilated cardiomyopathy
Clinical features in children	Transient depression of myocardial contractility	Restrictive cardiomyopathy and/or dilated cardiomyopathy	Restrictive cardiomyopathy and/or dilated cardiomyopathy
Course	Usually reversible on discontinuation of anthracycline	Can be progressive	Can be progressive

From Adams et al. [15]. Reprinted with permission from John Wiley & Sons, Inc.

^aData from Giantris et al. [16], and Grenier and Lipshultz [17].