Table 4.

Interaction between genes in candidate pathway

	Controls	Cases				Controls	Cases
Colon Cancer	N	N	OR	(95% CI)	N	N	OR	(95% CI)
	Akt1 (rs2494738)
RPS6KB1 (rs180531)	GG				GA/AA
AA	913	708	1.00		150	147	1.24	0.97,1.59
AG	643	499	1.01	0.86,1.17	104	72	0.88	0.64,1.21
GG	87	91	1.38	1.01,1.89	21	14	0.85	0.43,1.70
P Interaction			0.03
	RPS6KA2 (rs3799620)
RPS6KA1 (rs12025634)	AA/AG				GG
CC/CT	1638	1293	1.00		287	222	0.94	0.78,1.14
TT	30	33	1.44	0.87,2.38	1	8	10.27	1.28,82.29
P Interaction			0.02
	FRAP1 rs1057079
RPSK6A2 (rs2072638)	AA				AG/GG
TT	503	361	1.00		462	338	0.98	0.81,1.20
TC/CC	569	411	1.01	0.84,1.22	421	443	1.46	1.21,1.77
p interaction			0.005
	NFκB1 (rs4648110)
RPS6KA2 (rs395475)2	TT				TA/AA
TT	391	312	1.00		225	202	1.12	0.88,1.43
TC	628	484	0.96	0.80,1.17	326	261	1.01	0.81,1.26
CC	227	204	1.12	0.88,1.43	162	96	0.73	0.54,0.98
P Interaction			0.01
Rectal Cancer	PIK3CA (rs7640662)
RPS6KB1 (rs180519)	CC				CG/GG
GG	173	175	1.00		84	40	0.48	0.31,0.74
GA	382	308	0.8	0.62,1.03	103	72	0.71	0.49,1.02
AA	180	129	0.69	0.50,0.94	34	29	0.85	0.50,1.46
P Interaction			0.005
	PRKAG2 (rs1104897)
RPS6KB1 (rs180515)	GG				GA/AA
AA	305	197	1.00		92	118	1.95	1.41,2.71
AG	301	237	1.23	0.96,1.58	137	108	1.20	0.88,1.64
GG	80	63	1.22	0.84,1.77	43	30	1.08	0.65,1.78
P Interaction			0.002
	PIK3CA (rs7640662)
RPS6KB2 (rs917570)	CC				CG/GG
CC	251	216	1.00		70	66	1.13	0.77,1.67
CG	346	274	0.94	0.74,1.20	99	53	0.65	0.44,0.96
GG	129	110	1.03	0.74,1.41	49	20	0.49	0.28,0.85
P Interaction			0.009
	NFκB1 (rs4648110)
RPS6KA2 (rs7745781)3	TT				TA/AA
AA	454	335	1.00		276	185	0.91	0.72,1.16
AG/GG	159	137	1.15	0.88,1.50	70	97	1.90	1.35,2.67
P Interaction			0.009

¹Adjusted for age, center, race/ethnicity, and sex.

²Same association seen with NFκB1 (rs13117745)

³Same association seen with NFκB1 (rs13117745)