Table 5.
Interaction between RPS6KA1, RPS6KA2, BMI, estrogen exposure and awspirin/NSAID use and colon and rectal cancer
| Controls | Cases | Controls | Cases | Controls | Cases | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | N | OR | (95% CI) | N | N | OR | (95% CI) | N | N | OR | (95% CI) | ||
| Colon | BMI | ||||||||||||
| RPS6KA1 rs12025634 | <25 | 25 to <30 | 30 | ||||||||||
| CC/CT | 743 | 495 | 1.00 | 784 | 614 | 1.16 | (0.99, 1.36) | 397 | 404 | 1.49 | (1.25, 1.79) | ||
| TT | 16 | 11 | 1.06 | (0.49, 2.31) | 12 | 17 | 2.21 | (1.04, 4.67) | 3 | 13 | 6.26 | (1.77, 22.15) | |
| P Interaction | 0.04 | ||||||||||||
| Recent estrogen exposure | |||||||||||||
| RPS6KA1 rs12025634 | No | Yes | |||||||||||
| CC/CT | 514 | 438 | 1.00 | 356 | 216 | 0.59 | (0.45, 0.76) | ||||||
| TT | 9 | 12 | 1.60 | (0.67, 3.87) | 6 | 7 | 1.09 | (0.36, 3.35) | |||||
| P Interaction | 0.01 | ||||||||||||
| Rectal | Recent aspirin/NSAID use | ||||||||||||
| RPS6KA2 rs2072638 | No | Yes | |||||||||||
| TT | 249 | 245 | 1.00 | 250 | 120 | 0.50 | (0.37, 0.66) | ||||||
| TC | 214 | 162 | 0.80 | (0.61, 1.06) | 150 | 110 | 0.77 | (0.57, 1.05) | |||||
| CC | 53 | 65 | 1.30 | (0.87, 1.96) | 25 | 37 | 1.57 | (0.92, 2.70) | |||||
| P Interaction | 0.00 | ||||||||||||
Adjusted for age, center, race/ethnicity, and sex.