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. 2011 Feb 7;2011:431068. doi: 10.4061/2011/431068

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Copyright © 2011 Qi Xu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Protection of IP6 against 6-OHDA-induced apoptosis in the iron-excess condition in vitro cell culture model. Cell apoptosis was measured as caspase-3 activity (FU/mg protein, (a) n = 4-5-5 from one experiment) with 30 and 100 μmol/L IP6. DNA fragmentation (AU/mg protein, (b) n = 3-4-4 from one experiment) and Hoechst nuclear staining (c) were tested with only 30 μmol/L of IP6. ANOVA with Tukey's Multiple Comparison test was used to detect the differences among the treatments in (a) and (b), and means with different letters were significantly different (P < .05). The top panel in C represents 20x magnification and the bottom panel represents 60x magnification. Apoptotic nucleus is indicated with an arrow.