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. Author manuscript; available in PMC: 2012 Feb 9.
Published in final edited form as: J Am Chem Soc. 2011 Jan 11;133(5):1553–1562. doi: 10.1021/ja109207m

Figure 2.

Figure 2

Time- and concentration-dependent inactivation of DDAH by 1 at pH 7.5 (A) Exponential fits to the observed inactivation of DDAH at pH 7.5 and 25 °C by different concentrations of inhibitor: 0 (○), 83 μM (λ), 140 μM (□), 330 μM (ν), 600 μM (△), 1 mM (▲), 2 mM (◇), and 3 mM (◆). (B) Concentration dependence of the pseudo-first-order kobs values give a second order rate constant of 4.8 ± 0.3 M−1 s−1 for inactivation.