Figure 6.

Time-dependent inactivation of DDAH by 11 and protection by glutathione. The observed DDAH inactivation rate by 11 (300 μM, λ) is faster than that of 1 (300 μM, ▲, taken from Figure 1). However, preincubation of 11 with glutathione (5 mM) prevents any time-dependent inhibition of DDAH (ν, dashed line).