Table 1.

Inhibition of β-hematin formation, partition coefficient and antiplasmodial activities of complex 1 and CQDP

Complexes	Inhibition of β-hematin formation	HAI50 (mM) in buffera	HAI50 (mM) in interfaceb	Log Kc	Effect on the in vitro growth strains of P. falciparum (IC50 nM)d
					FCB1	FCB2
[Au(CQ)(PPh3)]PF6	+	3.42 ± 1.89 (0.1)	0.64 ± 0.02 (5)	7.69 ± 0.01	5.1	23
CQDP	+	0.35 ± 0.09 (1)	3.38 ± 0.13 (1)	5.84 ± 0.01	47	110

HAI₅₀ is the drug-to-hemin ratio required to inhibit 50% of heme aggregation against a control experiment in the absence of drugs.

^aValues in parentheses are the relative activity with respect to CQDP.

^bAfter 24-h reaction.

^cAfter 2 h reaction.

^dAt 25°C.