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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Shock. 2011 Feb;35(2):178–183. doi: 10.1097/SHK.0b013e3181f221fb

Fig. 3. Inhibition of A3 receptors increases the suppressive effect of HS on PMN.

Fig. 3

Purified human PMN were treated with the indicated concentrations of HS either with (circles) or without (diamonds) MRS-1191 at a final concentration of 1 nM. HS +/− MRS-1191 was added either 5 min before (open symbols; left panel) or 5 min after cell stimulation (solid symbols; right panel) with fMLP (100 nM). PMN activation was determined by assessing degranulation by measuring elastase release. Data expressed as mean ± SD are representative of at least 3 individual experiments with PMN from different donors. Statistical analysis: ANOVA, Bonferroni; *p<0.01.