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. 2011 Feb 15;22(4):503–512. doi: 10.1091/mbc.E10-06-0541

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© 2011 Ichi et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 9: — Hypothetical model for the regulation of Hes1 and Neurog2 via Pax3 and SIRT1. Pax3 is acetylated by acetyltransferase; acetylated Pax3 binds to Hes1 and Neurog2 promoters. When SIRT1 is associated with Hes1 promoter, deacetylated Pax3 up-regulates Hes1 expression. When SIRT1 is associated with Neurog2 promoter, deacetylated Pax3 does not up-regulate Neurog2. The overall effect is stem cell proliferation and maintenance. When SIRT1 is not associated with these promoters, acetylated Pax3 binds the promoters resulting in down-regulation of Hes1 and up-regulation of Neurog2. The overall effect is promotion of neurogenesis.