Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Feb 15;22(4):513–523. doi: 10.1091/mbc.E10-07-0560

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 Novotný et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

“ASCB®,“ “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology.

PMC Copyright notice

FIGURE 2: — Kinetic model of tri-snRNP assembly in the CB. (A) Full (WT) model of tri-snRNP formation in CBs. The CB is modeled as a spherical object with a permeable surface. Coefficients k_U4, k_U6, k_U5, k_U4/U6, and k_U4/U6.U5 describe transfer rates of U4, U6, U5, U4/U6, and U4/U6.U5 complexes, respectively, between nucleoplasm and CB. k_S3 denotes the transfer rate of SART3 protein (S3). Constant k₁ characterizes formation rate of U4/U6 di-snRNP complex from U4 and U6 components. Constant k₂ describes the conjugation rate of U4/U6 di-snRNP and U5 into U4/U6.U5 tri-snRNP. (B) Simplified (KO) model with blocked tri-snRNP formation. Depletion of hPrp6 inhibits tri-snRNP assembly and reduces the model to di-snRNP assembly.