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. Author manuscript; available in PMC: 2011 Feb 14.
Published in final edited form as: Clin Infect Dis. 2010 May 15;50(10):1405–1414. doi: 10.1086/652151

Figure 3.

Figure 3

The dynamics of nevirapine (NVP)–resistant human immunodeficiency virus type 1 (HIV-1) varying by time of infection. Wild-type virus was detected at birth in all infants infected in utero. Mutants selected by NVP replicated to high concentrations in infants with established in utero infections (panel A; infant identification numbers listed in boxes to the right of the graphs) then waned after NVP pressure subsided. NVP-resistant HIV-1 replicated to high concentrations in infants with acute in utero infections (panel B) and persisted as the majority genotype during the first months of life. A single mutant variant was apparently transmitted to most infants with peripartum infection (panel C), and this genotype persisted at high concentrations over time, compared with established in utero infections (P =.017). The prolonged persistence of mutants in both infants with acute in utero and peripartum infections suggests that mutants infected a large population of susceptible cells during primary infection.