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Effect of particle size on particle distribution in the eye. Collaged fluorescence microscopy images of tissue cryosections show the delivery of a 20 nm particles and b 1,000 nm particles into the suprachoroidal space of pig eyes ex vivo. The images show that 20 nm particles spread in the suprachoroidal space and within the sclera. However, the 1,000 nm particles are primarily in the suprachoroidal space. The insertion sites are magnified in the insets. Scale bar: 500 μm.
