Table 1.

Modifications of haemostatic factors during pregnancy.

Procoagulant factors
Fibrinogen (factor I)	↑
von Willebrand factor	↑
Factors VII, VIII, IX, X, XII	↑
Factors V, XIII	↑↓
Factor XI	C
Factor II	C
Coagulation inhibitors
Protein S	↓
Protein C, antithrombin III	=
Fibrinolytic factors
Tissue plasminogen activator	↓
Plasminogen activator inhibitor 1 and 2 (PAI-1, PAI-2)	↑
Thrombin activatable fibrinolysis inhibitor (TAFI)	↑
Others
Platelet count	↓
Prothrombin fragment 1+2	↑
Thrombin-antithrombin complex	↑
D-dimer, fibrinopeptide-A	↑

↑: increase; ↓: decrease; =: no significant change; ↑↓: early increase followed by decrease; C: controversial data.