Table 4.
Case reports describing the use of thrombolytic treatments in ischemic stroke during pregnancy and puerperium.
| Author, year | Thrombolysis | Dosage | Maternal age | Gestational age | Maternal complications | Fetal outcome | Associated conditions |
|---|---|---|---|---|---|---|---|
| Dapprich, 2002 | IV rt-PA | 0,9 mg/kg | 31 y | 12 week | minor hemorrhagic imbition of infarct area | good | Protein S deficiency |
| Elford, 2002 | IA rt-PA | 15.5 rng | 28 y | I week | hematoma in basal ganglia | good | Ovarian hyperstimulation syndrome |
| Johnson, 2005 | IA rt-PA | 15 rng | 39 y | 37 week | none | good | Undeterminated cause |
| Elevated IgG and IgM anti-cardiolipin | |||||||
| Leonhardt, 2006 | IV rt-PA | 0,9 mg/kg | 26 y | 23 week | basal ganglia infarction | good | Antibodies |
| Murugappan, 2006 | aIV rt-PA | 0,9 mg/kg | 37 y | 12 week | intrauterine hematoma | MTP | Mitral valve replacement |
| bIV rt-PA | 0,9 mg/kg | 31 y | 4 week | none | MTP | decreased protein S activity | |
| cIV rt-PA | 0,9 mg/kg | 29 y | 6 week | death from dissection during angioplasty | died | Aortic valve replacement | |
| dIA rt-PA | 21 rng | 43 y | 37 week | none | good | AT III, protein C and S deficiencies | |
| eIA UK | 600 000 U | 28 y | 6 week | buttock hematoma | good | protein C and S deficiencies, PFO | |
| flocal UK | 700 000 U | 25 y | frrst trimester | asymptomatic ICH | SA | bacterial endocarditis | |
| Wiese, 2006 | IV rt-PA | 0,9 mg/kg | 33 y | 13 week | none | good | mitral valve replacement |
| fifteen hours after | |||||||
| Mendez, 2008 | IA UK | 100 000 U | 37 y | cesarean delivery 6 days after | none | Undeterminated cause | |
| Ronning, 2010 | IA rt-PA | 20 rng | 29 y | delivery | none | Peripartum cardiomyopathy |
IV: intravenous; IA: intra-arterial; rt-PA: recombinant tissue plasminogen activator; UK: urokinase; ICH: intracerebral hemorrhage; MTP: medical termination of pregnancy; SA: spontaneous abortion.