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. 2011 Jan 19;108(6):2557–2562. doi: 10.1073/pnas.1012346108

Fig. 2.

Fig. 2.

Channels responsible for action potentials in C. elegans body wall muscles. (A) Representative single action potentials from WT and channel mutant muscles. Pronounced changes in kinetics were present in egl-19(n582,lf), egl-19(ad1006,lf), and shk-1(lf) but absent from unc-36(lf) and slo-1(gf) mutants. Dashed lines, −20 mV. (B) Quantification of the half-width and peak amplitude of action potentials in the respective channel mutants. An extension of duration was observed in egl-19(n582,lf), egl-19(ad1006,lf), and shk-1(lf). There was an increase of the peak amplitude in shk-1(lf) mutants but a decrease in egl-19(ad1006,lf) mutants. (C) Representative traces for trains of spontaneous action potentials in WT and mutant animals. (D Upper) The frequency of action potentials was decreased in egl-19(n582,lf), egl-19(ad1006,lf), unc-36(lf), shk-1(lf), and slo-1(gf) mutants. (Lower) The resting membrane potential was elevated in egl-19(n582,lf) mutants. *P < 0.05; **P < 0.01; ***P < 0.001; t test against WT. (Error bars = SEM.)