Fig. 5.
Sendai virus-mediated activation of an IRF-3 promoter. Full-length NP (NP-FL), the N-terminal domain of NP (NP1–340), the C-terminal domain of NP (NPΔ340), and amino acid substitutions of full-length NP were assayed for inhibition of Sendai virus-mediated activation of an IRF-3–dependent promoter. Values displayed reflect relative luminescence units corrected to an uninfected, empty vector control. E(−) and E(+) indicate an uninfected empty vector control and an infected empty vector control, respectively. Note that the wild-type function of NP is to block IRF-3 translocation and therefore block reporter luminescence.