Fig. 4.
MIC-reactive Vδ1 γδ TCR sequences and CDR surface conservation mapped onto the δ1A/B-3 structure. (A) Amino acid sequences of three MIC-responsive Vδ1 γδ TCR clones are shown, designated as δ1A/B-1, δ1A/B-3, and δ1A/B-5 (10), with CDR loops highlighted in red. (B and C) Two views of the δ1A/B-3 structure are shown as ribbons (Left) or molecular surfaces (Right). Identical CDR residues are colored red, identical framework residues are colored green, conservatively substituted residues are colored orange throughout, and nonconserved residues are colored gray throughout.