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. 2011 Jan 20;108(6):2468–2473. doi: 10.1073/pnas.1003403108

Fig. 1.

Fig. 1.

Structure and expression of Hemp. (A) Comparison of amino acid sequences of mouse Hemp (Upper) and human Hemp (Lower) proteins. Vertical lines indicate identical amino acids. Zinc-finger domain cysteine residues are circled, a nuclear localization signal is underlined, and each of the four mbt repeats is shown in boldface surrounded by a box. (B) Alignment of the four mbt repeats of mouse Hemp with the mbt consensus sequences. Identical and similar amino acids to the consensus sequences are indicated by black and gray backgrounds, respectively. Amino acid numbers are shown in parentheses. (C) Comparison of the primary structures of previously reported mbt-containing proteins. The proteins are divided into two groups, SPM(+) and SPM(−), depending on whether or not they possess the SPM domain (shown as a black box). The mbt domain and the C2C2/C2HC Zinc-finger domain are indicated by gray and shaded boxes, respectively. (D) Expression of hemp RNA in mouse tissues and in human hematopoietic and nonhematopoietic cell lines. The position of hemp is indicated by an arrow. Hybridization with β-actin cDNA is shown as an internal control.