Table 3.

Sleep parameters in groups of children with Major Depressive Disorder (MDD) and Healthy Controls (HC) in relation to Body Mass Index (Mean ± SD)¹

	MDD (N=73)		HC (N=32)		MANCOVA
	Normal weight	≥ 85 percentile	Normal weight	≥ 85 percentile	F	p
N	43	29	20	12
1) Total Sleep Time (min)	471.38 ± 51.22	471.79 ± 52.58	454.58 ± 41.58	490.13 ± 50.18		NS
2) Sleep Efficiency, %	93.32 ± 3.24	91.61 ± 3.98	93.34 ± 3.60	93.58 ± 2.09		NS
3) Sleep Latency (min)	16.15 ±13.10	16.45 ± 14.60	10.52 ± 10.02	13.92 ± 10.95		NS
4) % Awake-&-Movement time	3.61 ± 1.71	5.29 ± 2.57	4.69 ± 3.20	3.92 ± 1.40	6.32	0.014*
5) Sleep Stage 1 %	7.74 ± 4.57	11.27 ± 6.90	9.19 ± 4.69	9.63 ± 7.41		NS
6) Sleep Stage 2%	50.10 ± 7.99	49.21 ± 6.95	49.80 ± 6.79	45.78 ± 9.24		NS
7) Slow Wave Sleep %	18.92 ± 8.06	16.48 ± 6.43	18.45± 5.74	19.89 ± 5.86		NS
8) REM Latency (min)	115.09 ± 50.42	106.28 ± 64.84	97.22 ± 36.59	108.12 ± 51.38		NS
9) REM Sleep %	19.62 ± 4.76	17.75 ± 4.97	17.87 ± 4.01	20.77 ± 3.79	6.63	0.012*
10) REM Density	2.28 ± 0.60	2.10 ± 0.54	1.95 ± 0.57	2.37 ± 0.82	4.52	0.036*
Time spent awake & moving in middle 3rd of night (min)	7.15 ± 5.18	10.03 ± 8.50	10.08 ± 10.42	6.83 ± 3.98	3.98	0.049**
Time spent awake & moving in last 3rd of night	6.67 ± 4.62	11.74 ± 9.22	7.42 ± 4.41	7.08 ± 2.91	4.42	0.038**
1st REM period duration (min)	15.88 ± 12.79	9.62 ± 6.29	12.23 ± 8.35	17.29 ± 9.28	7.42	0.008**
1st REM period net REM time (min)	14.02 ± 11.77	8.03 ± 5.41	9.03 ± 6.46	14.63 ± 9.45	9.44	0.003**
REM Density 1st period	1.61 ± 0.75	1.29 ± 0.69	1.29 ± 0.80	1.68 ± 1.07	4.20	0.043**

¹Means ± SD are unadjusted

^*p-values for 1^st MANCOVA with ten dependent sleep variables showing that the interaction between diagnostic group and BMI group was significant while controlling for sex and Tanner stage score.

^**p-values for 2^nd MANCOVA with five of 12 dependent sleep variables by time period, showing that the interaction between diagnostic group and BMI group was significant while controlling for sex and Tanner stage score