Table 7. Single CNA of interest.
Patients | MCR unic cases | Size (Mb) | Possible genes |
t-AML | |||
t-2 | +14q22.1 <47.25–52.51> | 5.26 | >30 genes |
t-2 | −18q11.2q12.1<21.74–24.41>[0.23] | 2.67 | SS18 (Synovialosarcoma translocation) +7 other genes |
t-2 | −18q22.3q23<71.06–71.76> | 0.69 | TSHZ1 Colon cancer ag a zinc finger protein |
t-13 | −1q42.3.q44<233.13–247.19> | 14.06 | >100 genes |
t-13 | −10q11.2<45.53–47.97> | 2.44 | >20 genes |
t-5 | −12p13.2p13.1<11.82–13.33> | 1.51 | >20 genes ETV6 CDKN1B miR613 miR614 miR1244 |
t-22 | +2p25.3 <2.54–3.57> | 1.03 | TSSC1 TTC15 ADI1 RNASEH1 |
t-14 | −17q11.2 <25.96–27.38> | 1.42 | EVI2A EVI2B NF1 OMG SH3GLP2 SUZ12 CRLF3 C17orf79 |
CENTA2 UTP6 C17orf42 ATAD5 RNF135 RAB11FIP4 | |||
LRRC37B SUZ12P miR193a miR365-2 | |||
t-15 | −4q31.2 <146.62–146.67> | 0.05 | SMAD1 |
t-30 | −2p23.3<25.31–25.60> | 0,10 | DNMT3A miR1301 |
p-AML | |||
p-24 | +3p21.3<50.26–50.29>[2.54] | 0.03 | GNAI2 SEMA3B |
p-24 | +3p21.3<52.29–52.31>[4.00] | 0.03 | NCLYTK miR135a-1 |
p-21 | +3p14.1<64.32–67.67>[4.59] | 1.94 | LR1G1 |
p-18 | −8q21.3q22.1<93.15–94.17>[0.63] | 1.02 | RUNXT1 |
p-22 | −12p12.1p13.2<11.40–21.20>[0.55] | 9.8 | ETV6 CDKN1B among more than 20 genes |
p-24 | −17p11.2q12<0.18–29.54>[0.65] | 29,36 | multiple genes |
p-24 | +15q23<67.44–68.37>[3.64] | 3.31 | KIF23 RPLP1 TLE3 miR-629 |
p-22 | −18q21.2<48.99–51.05>[0.55] | 2.06 | DCC and 4 other genes |
Column 2: The CNA were either lost or gained as indicated by a “−” or a “+”; the locations on chromosomes are described following the ISCN 2009 with slight modifications: sequence numbers are included between <> and expressed in Mb, with a resolution of 10kb; linear ratios are written between brackets after an “×”; chromosomes with a linear ratio >2 (low level of amplification) or losses <0.25 are labeled in bold and italics.