Table 8. Minimal critical regions in the literature including the present work: losses.
| Chromosome | All | p (%) | t (%) | consensus MCR | References | Genes |
| abnormalities | location in Mb | |||||
| 1p36.2 | 6 | 6 (1) | 7.81–7.89 | A, D, E | PER3 UTS2 | |
| 1p35.1 | 6 | 6 (1) | 22.39–22.44 | A, D, E | ||
| 1p34.2 | 3 | 3 (0.5) | 42.07–42.45 | A, D, E | KRC HIVEP3 | |
| 1p31.3p31.1 | 3 | 2 (0.3) | 1 (2) | 67.07–69.95 | A, D, E | WDR78 MIERS1 C1orf141 IL12RB2 SERBP1 |
| GADD45A GNG12 DIRAS3 GPR177 RPE65 DEPDC1 | ||||||
| 1q42.1 | 3 | 3 (0.5) | 222.6–222.9 | D | CNIH4 WDR26 CR625980 CNIH3 | |
| 1q44 | 2 | 2 (4) | 241.94–247.19 | K | WDR64 EXO1 MAP1LC3C PLD5?CEP170 AKT3 | |
| ZNF238 C1orf101 FAM36A EFCAB2 KIF26B | ||||||
| SMYD3 TFB2M ADSS HNRNPU PPPDE1 AHCTF1 | ||||||
| 2p23.3 | 3 | 3 (0.5) | 25.25–25.46 | D, E | ||
| 2p23.1 | 3 | 3 (0.5) | 30.29–30.95 | A, D, E | ||
| 2q36.2 | 8 | 8 (1.4) | 222.01–225.42 | A, D, E | EPHA4 PAX3 FARSB MOGAT1 ACSL3 KCNE4 AP1S3 | |
| WDFY1 SERPINE2 MRPL44 FAM124B CUL3 SCG2 | ||||||
| 3p26.3-p25.3 | 4 | 3 (0.5) | 1 (2) | 0–9.14 | D, G | |
| 3p26.3 | 4 | 3 (0.5) | 1 (2) | 14.96–16.15 | A, D | |
| 3p21.3 | 8 | 5 (0.9) | 3 (6) | 44.46–49.64 | A, D, K | Numerous ZNF more than 30 genes |
| 3p14.1p12.3 | 3 | 3 (6) | 69.67–79.19 | A, K | MITF FOXP1 EIF4E3 GRP27 PROK2 RYBP SHQ1 | |
| PPP4R2 PDZRN3 CNTN3 FAM86D FRG2C ZNF717 | ||||||
| ROBO2 ROBO1 | ||||||
| 3q11.2q13.3 | 5 | 5 (0.9) | 95.03–120.21 | D, E | more than 30 genes | |
| 3q13.1q13.3 | 2 | 1 (0.2) | 1 (2) | 106.75–109.60 | D | |
| 3q13.3 | 3 | 2 (0.3) | 1 (2) | 117.78–118.40 | D | |
| 3q24q29 | 3 | 2 (0.3) | 1 (2) | 160.62–162.14 | D | |
| 3q24q29 | 3 | 2 (0.2) | 1 (2) | 164.51–165.39 | D | SI SLITRK3 CR612557 |
| 4q24 | 7 | 7 (1.2) | 106.1–106.72 | A, D | TET2 PPA2 FLJ20184 INTS12 GSTCD | |
| 4q27q28 | 6 | 5 (0.9) | 1 (2) | 122.92–124.45 | D | ADAD1 IL21 BBS12 FGF2 NUDT6 SPATA5 SPRY1 |
| 4q31.2 | 4 | 4 (8) | 146.62–146.67 | D, K | SMAD1 | |
| 5q11.1 | 3 | 2 (0.3) | 1 (2) | 50.16–50.21 | D | |
| 5q11.2 | 3 | 3 (0.5) | 51.79–53.66 | D | ||
| 5q11.2 | 5 | 4 (0.7) | 1 (2) | 55.73–56.92 | A, D | |
| 5q11.2 | 4 | 3 (0.5) | 1 (2) | 57.49–57.79 | A, D | |
| 5q12.1 | 7 | 5 (0.9) | 2 (4) | 59.54–59.87 | A, D, E | |
| 5q13 | 14 | 10 (1.9) | 4 (8) | 82.72–84.65 | A, D, E, J | VCAN HAPLN1 EDIL3 |
| 5q14.3q15 | 20 | 17 (3) | 3 (6) | 86.54–95.19 | A, D, E, J | CCNH TMEM161B MEF2C CETN3 POLR3G |
| RASA1 LYSMD3 GPR98 VLGR1 ARRDC3 NR2F1 | ||||||
| FAM172A POU5F2 ANKRD32 MCTP1 UNQ630 | ||||||
| TTC37 ARSK GPR150 RFESD RHOBTB3 GLRX | ||||||
| 5q15q22.3 | 20 | 16 (2.6) | 4 (8) | 95.51–114.14 | A, D, E, J | PCSK1 CAST ERAP1 ERAP2 LNPEP LIX1 2 |
| RIOK CHD1 PAM HISPPD1 NUDT12 | ||||||
| CR610784 RAB9P1 EFNA5 FBXL17 FER PJA2 | ||||||
| MAN2A1 TMEM232 TSLP WDR36 CAMK4 | ||||||
| STARD4 C5orf13 EPB41L4A APC SRP19 | ||||||
| ZRSR2 REEP5 DCP2 MCC YTHDC2 KCNN2 | ||||||
| 5q22.3q31.1 | 16 | 13 (2.3) | 3 (6) | 129.23–131.96 | A, D, E, J | CHSY3 LYRM7 CDC42SE2 RAPGEF6 FNIP1 ACSL6 |
| CSF2 IL3 P4HA2 PDLIM4 IRF1 RAD50 | ||||||
| 5q31.1 | 21 | 12 (2.1) | 9 (18) | 133.52–134.26 | A, D, E, H | PPP2CA CDKL3 UBE2B PHF15 SAR1B CAMLG |
| DDX46 C5orf24 TXNDC15 PCBD2 | ||||||
| 5q31.3q33.1 | 19 | 11 (2) | 8 (16) | 142.91–148.19 | A, D, E, J, K | HMHB1 YIPF5 PRELID2 GRXCR2 RBM27 POU4F3 LARS GPR151 PPP2R2B TCERG1 STK32A JAKMIP2 |
| SPINK1 SPINK5 SPINK6 SPINK7 SPINK9 FBXO38 | ||||||
| HTR4 SH3TC2 | ||||||
| 5q33.3 | 14 | 10 (1.8) | 4 (8) | 156.39–156.51 | A, D, E, J | |
| 5q33.3 | 13 | 10 (1.8) | 3 (6) | 157.25–158.80 | A, D, E, J | CLINT1 EBF1 RNF145 UBLCP1 IL12B |
| 6p25.1p24.3 | 10 | 7 (1.2) | 3 (6) | 5.54–8.38 | A, B, C, D | FARS2 NRN1 F13A1 LY86 MMD-1 Zep-1 |
| RREB1 SSR1 CAGE1 RIOK1 DSP BMP6 | ||||||
| TXNDC5 MUTEDEEF1E1 | ||||||
| 6p22.3p22.2 | 5 | 4 (0.7) | 1 (2) | 20.29–23.74 | A, B, D | |
| 6p22.2p22.1 | 6 | 5 (0.9) | 1 (2) | 24.15–26.16 | A, B, D | DCDC2 KAAG1 MRS2 GPLD1 ALDH5A1 TTRAP |
| ACOT13 GMNN FAM65B DKFZp686H12134 | ||||||
| HIST1H cluster TRIM38 HFE | ||||||
| 6q24.1 | 2 | 1 (0.2) | 1 (2) | 140.6–142.5 | D, F | |
| 6q25.3 | 2 | 1 (0.2) | 1 (2) | 156.39–156.61 | D | |
| 7p22.2 | 7 | 1 (0.2) | 6 (12) | 3.02–3.12 | D, K | CARD11 |
| 7p14.1 | 4 | 3 (0.5) | 1 (2) | 39.5–41.7 | D, F | |
| 7p12.2 | 2 | 2 (0.3) | 50.18–50.45 | D | IKZF1 | |
| 7q21.1 | 4 | 3 (0.5) | 1 (2) | 85.41–86.44 | A, C, E | |
| 7q21.1 | 5 | 5 (10) | 90.21–90.44 | A, D | PFTK1 | |
| 7q21.3q22.1 | 14 | 6 (1) | 8 (16) | 97.69–100.36 | A, D, E, K | LMTK2 BHLHA15 TECPR1 BRI3 NPTX2 |
| TMEM130 TRRAP SMURF1 KPNA7 MYH16 | ||||||
| ARPC1A PDAP1 BUD31 PTCD1 CPSF4 ATP5J2 | ||||||
| ZKSCAN5 CYP3A4 TRIM4 COPS6 MCM7 | ||||||
| TAF6 GATS PILRB PILRA ZCWPW1 MEPCE | ||||||
| FBXO24 GNB2 EPO mir-25 mir-93 mir-106b | ||||||
| 7q31.3 | 16 | 15 (2.7) | 1 (2) | 121.7–123.9 | B, D, F, J, K | PTPRZ1 LKR/SDH AASS FEZF1 CADPS2 RNF133 |
| TAS2R16 NDUFA5 ASB15 WASL HYAL4 | ||||||
| 7q33q34 | 22 | 15 (2.7) | 7 (14) | 135.74–137.48 | B, D, E, J, K | CALD1 TMEM140 STRA8 WDR91 |
| CNOT4 NUP205 FAM180A TPN miR490 | ||||||
| 7q34 | 20 | 19 (3.4) | 1 (2) | 139.72–140.02 | B, D, E, J, K | TBXAS1 PARP12 MST109 JHDM1D KIAA1718 |
| 7q35q36.1 | 16 | 16 (2.9) | 146.12–148.2 | B, D, E, J, K | CNTNAP2 | |
| 7q36.1q36.2 | 16 | 15 (2.7) | 1 (2) | 152.02–152.80 | A, B, D, E, J, | MLL3 XRCC2 ACTR3B FABP5L3 |
| K | ||||||
| 8p23.2 | 3 | 2 (0.3) | 1 (2) | 3.48–3.58 | A, D | |
| 8p22p21.3 | 2 | 1 (0.2) | 1 (2) | 18.72–21.93 | D | |
| 8p21.2p12 | 2 | 1 (0.2) | 1 (2) | 24.40–36.30 | D | |
| 8q22.1 | 3 | 3 (0.5) | 93.15–94.17 | A, K | C8orf83 | |
| 8q24.1 | 4 | 3 (0.5) | 1 (2) | 117.81–118.38 | I | |
| 8q24.1q24.2 | 4 | 3 (0.5) | 1 (2) | 126.54–129.58 | A, D | |
| 8q24.2 | 3 | 3 (0.5) | 130.53–130.80 | A, D | ||
| 8q24.2q24.3 | 3 | 2 (0.3) | 1 (2) | 131.51–146.26 | A, D | |
| 9p24.3p13.3 | 4 | 4 (0.7) | 0.19–33.18 | A, D, E | ||
| 9q21.3 | 5 | 4 (0.7) | 1 (2) | 82.37–84.44 | B, C, D, E | |
| 9q22.3q31.1 | 5 | 5 (0.9) | 93.92–103.96 | C, D, E, K | more than 30 genes | |
| 9q32q33.1 | 2 | 2 (0.3) | 116.51–117.92 | B, D | ||
| 10q23.1q23.3 | 4 | 4 (0.7) | 87.93–90.77 | C, D | ||
| 10q24.1q24.2 | 4 | 4 (0.7) | 96.48–100.81 | C, D | ||
| 11p15.5p15.4 | 8 | 7 (1.2) | 1 (2) | 2.48–3.35 | B, C, D, E | KCNQ1 KCNQ1OT1 KCNQ1DN CDKN1C |
| SLC22A18NAP1L4 PHLDA2 CARS | ||||||
| OSBPL5 C11orf36 MRGPRE | ||||||
| 11q12.3q13.1 | 3 | 3 (0.5) | 63.98–65.65 | D | ||
| 11q13.1q25 | 4 | 4 (0.7) | 67.25–134.24 | B, D, E | ||
| 11q23.3 | 4 | 2 (0.3) | 2 (4) | 117.86–119.81 | A, D, E | |
| 12p13.3 | 4 | 2 (0.3) | 2 (4) | 0.06–4.05 | D, E | |
| 12p13.2 | 10 | 6 (1) | 4 (8) | 10.62–11.72 | C, D, E, J | |
| 12p13.2 | 12 | 10 (1.8) | 2 (4) | 11.2–12.70 | C, D, E, F, J | |
| 12p13.2p13.1 | 17 | 14 (2.5) | 3 (6) | 12.20–13.13 | C, D, E, J, K | ETV6 BCL2L14 LRP6 MANSC1 LOH12CR1 |
| AX748225 DUSP16 CREBL2 GPR19 CDKN1B | ||||||
| APOLD1 DDX47 GPRC5A TVAS4 HEBP1 | ||||||
| 12p12.3 | 7 | 5 (0.9) | 2 (4) | 15.54–19.17 | C, D, E, J, K | PTPRO EPS8 STRAP MGST1 LMO3 RERGL PIK3C2G |
| CAPZA3 | ||||||
| 12q12 | 3 | 2 (0.3) | 1 (2) | 42.64–43.26 | A, D | |
| 12q13.1 | 2 | 2 (0.3) | 46.06–46.30 | A, D | ||
| 12q24.3 | 4 | 3 (0.5) | 1 (2) | 81.57–105.06 | A, D, E | |
| 12q24.3 | 3 | 2 (0.3) | 1 (2) | 121.28–122.73 | A, D | |
| 12q24.3 | 3 | 3 (0.5) | 128.71–128.91 | A, D, E | ||
| 13q14.3 | 8 | 7 (1.2) | 1 (2) | 49.63–50.51 | C, D, E | |
| 13q21.1 | 4 | 4 (0.7) | 54.33–54.45 | B, D | ||
| 16p11.1q12.1 | 20 | 20 (3.6) | 35.06–50.12 | D, G | VPS35 SHCBP1 ORC6L MYLK3 GPT2 DNAJA2 | |
| NETO2 ITFG1 PHKB ABCC12 ABCC11 LONP2 SIAH1 | ||||||
| LONP N4BP1 CBLN1 HEATR3 | ||||||
| 16q21 | 24 | 23 (4.1) | 1 (2) | 57.56–58.96 | B, D, G | GPR114 GPR56 GPR97 CCDC135 KIFC3 CNGB1 |
| TEPP MMP15 CSNK2A2 GINS3 NDRG4 SETD6 | ||||||
| CNOT1 GOT2 | ||||||
| 16q21 | 26 | 24 (4.3) | 2 (4) | 62.51–63.81 | D, G, J | |
| 16q22.3 | 25 | 22 (4) | 3 (6) | 70.76–71.46 | D, G, J | VAC14 HYDIN FTSJD1 CALB2 |
| 16q22.3q23.1 | 26 | 26 (4.7) | 73.30–73.57 | G, H, J | BC042734 | |
| 16q24.1 | 24 | 23 (4.1) | 1 (2) | 83.37–85.07 | D, G, J | CDH13 HSBP1 MLYCD OSGIN1 NECAB2 MBTPS1 |
| HSDL1 LRRC50 TAF1C ADAD2 KCNG4 USP10 | ||||||
| 16q24.3 | 26 | 26 (4.7) | 87.30–87.37 | G, J, K | FBXO31 | |
| 17p13.2p13.1 | 22 | 16 (2.9) | 6 (12) | 4.01–8.20 | A, D, J | TP53 NLRP1 NUP88 C1QBP XAF1 and more than |
| 30 genes | ||||||
| 17p12p11.2 | 7 | 5 (0.9) | 2 (4) | 14.74–19.35 | A, D, E | |
| 17p11.2 | 4 | 3 (0.5) | 1 (2) | 20.02–21.45 | C, D, E | |
| 17q11.2 | 44 | 39 (7.1) | 5 (10) | 26.49–27.52 | A, D, E, G, | NF1 EVI2A EVI2A |
| H, J, K | ||||||
| 17q21.33 | 4 | 2 (0.3) | 2 (4) | 44.98–45.43 | D, E | |
| 17q21.33 | 3 | 3 (0.5) | 46.22–47.56 | D, E | ||
| 17q25.1q25.3 | 2 | 2 (0.3) | 69.43–73.16 | D | ||
| 18p11.32p11.31 | 14 | 12 (2.1) | 2 (4) | 1–4.62 | D, G, J | C18orf2 METTL4 NDC80 SMCHD1 EMILIN2 |
| LPIN2 MYOM1 MYL12B TGIF1 DLGAP1 | ||||||
| 18p11.23 | 17 | 16 (2.9) | 1 (2) | 7.42–7.58 | G, H, J | PTPRM |
| 18p11.22p11.21 | 5 | 4 (0.7) | 1 (2) | 9.03–13.81 | D, H | |
| 18q11.2 | 9 | 8 (1.4) | 1 (2) | 18.1–22.05 | D, G | |
| 18q11.2q12.2 | 21 | 18 (3.2) | 3 (6) | 21.74–33.13 | D, G, K | CABYR OSBPL1A IMPACT HRH4 ZNF521 SS18 |
| PSMA8 TAF4B CDH2 DSC3 DSC1 DSC2 DSG4 | ||||||
| DSG3 DSG2 TTR RNF125 DTNA MAPRE2 | ||||||
| 18q21.1 | 21 | 20 (3.6) | 1 (2) | 43.39–46.37 | D, E, G, K | HAUS1 LOXHD1 PIAS2 SMAD2 |
| 18q21.2 | 22 | 20 (3.6) | 2 (4) | 50.21–51.05 | D, E, G, K | RAB27B CCDC68 |
| 18q21.32 | 22 | 20 (3.6) | 2 (4) | 55.08–55.51 | D, E, G, J, K | ONECUT2 FECH NARS ATP8B1 |
| 18q22.3 | 23 | 22 (4.0) | 1 (2) | 69.06–69.18 | D, E, G, K | |
| 18q22.3q23 | 4 | 2 (0.3) | 2 (4) | 71.06–71.76 | E, G, J | FBXO15 |
| 19p13.3 | 3 | 2 (0.3) | 1 (2) | 0.21–1.81 | A, D | |
| 19q13.2q13.43 | 2 | 2 (0.3) | 46.16–63.43 | C, D | ||
| 20q11.2q13.1 | 2 | 2 (0.3) | 34.59–43.45 | E | more than 30 genes | |
| 20q13.1q13.3 | 2 | 2 (0.3) | 43.85–55.73 | E | more than 30 genes | |
| 21q22.12 | 11 | 7 (1.2) | 4 (8) | 35.11–35.15 | A, D, K | RUNX1 |
| 21q22.3 | 3 | 3 (0.5) | 44.70–45.09 | D |
The first column lists the chromosomal losses and gains. The second lists the absolute number of each rearrangement (excluding a single rearrangement). The third and the fourth are the absolute numbers in p-AML and t-AML respectively and the percentage is indicated between parenthesis. The chromosomal location is listed. The references are indicated by letters: A [32], B [33], C [34], D [18], E [19], F [28], G [29], H [30], I [31], J [20], K present work. The last column lists the genes included in those MCR.