Table 9. Minimal critical regions in the literature including the present work: gains.
| Chromosome | All | p (%) | t (%) | consensus MCR | References | Genes |
| abnormalities | location in Mb | |||||
| GAINS | ||||||
| 1q21.3q22 | 4 | 3 (0.5) | 1 (2) | 153.19–154.64 | C, D, K | S100A8 S100A9 S100A13 S100A6 SNAPIN ILF2 |
| NPR1 INTS3 VLCS-3 GATAD2B TORC2 CREB3L4 | ||||||
| TPM3 HAX1 IL6R SHE UBE2Q1 ADAR CHRNB2 | ||||||
| 1q32.1 | 3 | 2 (0.3) | 1 (2) | 204.98–205.04 | C, D | |
| 1q32.1q44 | 6 | 5 (0.9) | 1 (2.1) | 235.00–235.10 | A, B, K | BC016972 ? |
| 3q26.3q29 | 2 | 2 (0.3) | 182.99–133.31 | E | more than 30 genes | |
| 4p13q12 | 2 | 2 (0.3) | 42.30–58.23 | B, D | ||
| 4q12q13.1 | 2 | 2 (0.3) | 59.13–62.98 | B, D | ||
| 4q28.3 | 2 | 2 (0.3) | 132.8–136.7 | B, G | ||
| 5p13.2q11.1 | 2 | 1 (0.2) | 1 (2) | 37.98–50.15 | A, D | |
| 5q11.2 | 3 | 2 (0.3) | 1 (2) | 51.21–54.12 | A, D | |
| 6q11.2q12 | 8 | 8 (1.4) | 63.43–63.7 | A, G | ||
| 6q27 | 3 | 2 (0.3) | 1 (2) | 168.12–168.32 | D, K | MLLT4 avoir table 6 |
| 7p15.2 | 4 | 4 (8) | 27.15–27.18 | K | HOX genes | |
| 8q24.3 | 16 | 12 (2.1) | 4 (8) | 143.73–143.90 | B, D, G, I, J, K | JRK PSCA LY6K C8orf55 LYPD2 SLURP1 LYNX1 |
| LY6D | ||||||
| 9p21.3 | 2 | 2 (0.3) | 21.5–23.4 | F, G | ||
| 9q13q21.3 | 2 | 2 (0.3) | 70.23–83.52 | E | FXN APBA1 TJP2 SMC5 TRPM3 GDA TCM1 ANXA1 | |
| RARB RFK GNA14 TLE4 TLE1 | ||||||
| 11q12.1q14.1 | 16 | 16 (2.9) | 59.1–79.6 | G | more than 50 genes | |
| 11q14.1 | 5 | 5 (0.9) | 79.6–81.3 | D, G | ||
| 11q24.2q24.3 | 31 | 31 (5.6) | 126.53–130.23 | D, E, G, J | KIRREL3 ETS1 FLI1 C11orf45 TP53AIP1 RICS | |
| BARX2 NFRKB PRDM10 APLP2 ST14 ZBTB44 | ||||||
| 12p13.33p11.21 | 13 | 13 (2.3) | 0.1–32.7 | E, G | no gene | |
| 13q12.11q13.1 | 3 | 3 (0.5) | 19.9–31.7 | G | ||
| 13q31.3 | 2 | 2 (0.3) | 90.45–90.97 | E | GPC5 | |
| 15q21.1 | 3 | 3 (0.5) | 46.52–47.36 | B, D, E | ||
| 15q21.3q22.1 | 3 | 3 (0.5) | 55.6–56.6 | B, E, F | ||
| 15q23 | 5 | 5 (0.9) | 67.44–68.37 | B, E, J | SMAD3 AAGAB MAP2K5 LBXCOR1 PIAS1 | |
| 15q26.q26.3 | 6 | 6 (1) | 92.5–100.0 | C, E, G | ||
| 17q12 | 6 | 4 (0.7) | 2 (4) | 32.82–33.20 | C, D, E, J | TMEM132E |
| 17q21.2q21.31 | 5 | 3 (0.5) | 2 (4) | 37.08–38.48 | D, E, J | FBXO47 PLXDC1 FBXL20 MED1 CRKRS TCAP |
| PGAP3 ERBB2 GRB7 IKZF3 GSDMB ORMDL3 | ||||||
| PSMD3 CSF3 MED24 THRAP4 NR1D1 MSL1 CASC3 | ||||||
| WIPF2 CDC6 RARA | ||||||
| 19p13.3p13.12 | 13 | 13 (2.3) | 2.19–14.11 | D, G, J | ||
| 19p13.12p13.11 | 13 | 13 (2.3) | 16.0–16.15 | F, G, J | ||
| 19q13.31 | 2 | 2 (0.3) | 49.2–49.9 | D, F | ||
| 19q13.41 | 2 | 2 (0.3) | 58.3–59.1 | D, G | ||
| 20q11.1q11.21 | 3 | 3 (0.5) | 28.2–30.5 | E, G | ||
| 21q21.1 | 2 | 2 (0.3) | 14.29–17.97 | K | LIPI ABCC13 RBM11 HSPA13 SAMSN1 NRIP1 | |
| USP25 C21orf34 CXADR BTG3 | ||||||
| miR-99a miR-125b-2 hsa-let-7c | ||||||
| 21q22.2 | 18 | 18 (3.2) | 38.65–38.85 | C, D, G, J, K | ERG ETS2 | |
| 21q22.3q | 4 | 4 (0.7) | 45.09–46.91 | D, K | RRP1B PDXK RRP1 CSTB AGPAT3 TRAPPC10 | |
| TMEM1 PWP2 C21orf33 ICOSLG DNMT3L AIRE | ||||||
| PFKL TRPM2 LRRC3 UBE2G2 SUMO3 PTTG1IP PBF | ||||||
| ITGB2 ADARB1 COL18A1 | ||||||
| 22q12.3 | 13 | 12 (2.1) | 1 (2) | 33.90–35.32 | D, G | LARGE |
| 22q13.1q13.2 | 14 | 13 (2.3) | 1 (2) | 36.78–42.24 | D, G | more than 30 genes |
| 22q13.31q13.32 | 11 | 10 (1.8) | 1 (2) | 44.92–48.08 | D, G | PRR5 ARHGAP8 PHF21B NUP50 UPK3A SMC1B |
| ATXN10 WNT7B GTSE1 GRAMD4 |
The first column lists the chromosomal losses and gains. The second lists the absolute number of each rearrangement (excluding a single rearrangement). The third and the fourth are the absolute numbers in p-AML and t-AML respectively and the percentage is indicated between parenthesis. The chromosomal location is listed. The references are indicated by letters: A [32], B [33], C [34], D [18], E [19], F [28], G [29], H [30], I [31], J [20], K present work. The last column lists the genes included in those MCR.