Table 1. Demographic and clinical characteristics of the cohort.

Demographics	MS	Controls	p-value
Females: Males (% Female)	201: 67 (75%)	83*: 72 (54%)	<0.001‡
Disease course:Relapsing-remittingSecondary progressiveRelapsing SPPrimary progressive or primary relapsing	182 (67.9%)182 (67.9%)18 (6.7%)11 (4.1%)
Race/Ethnicity:Caucasian-AmericanAfrican-AmericanHispanic/LatinoAsianOther/Unknown/Not given	243 (93.1%)13 (5.0%)4 (1.5%)0 (0%)1 (0.4%)	136 (89.5%)136 (89.5%)1 (0.7%)4 (2.6%)0 (0%)	0.20#
Age, years	46.4±12.1	44.8±14.1	0.24¶
Disease duration*, years	14.8±10.7	–
Median EDSS* (IQR)	2.5 (4.0)

The continuous variables are expressed as mean ± SD and the categorical variables as frequency (%).

*1 subject self-reported as transgender male, counted as a male.

^#Fisher exact test for frequency of Whites to Non-whites in MS vs. Controls. For frequency of Black/African Americans to non-Black/African-Americans in MS vs. Controls p = 1.

^‡Fisher exact test.

^¶ t-test.