Figure 5. Expression of D-CblL and RING-SH2^Drk promotes the lysosomal sorting of the Grk-receptor complex.

(A–F) Some HRP signals were colocalized with Rab5-GFP signals in wild-type follicle cells (A, A′ and arrow in B), and more colocalized signals of HRP and Rab5 were detected in follicle cells expressing RING-SH2^Drk (C, C′ and arrowhead in D), and in cells expressing D-CblL (E, E′ and arrowhead in F). (G–L) Similarly, significantly more colocalized signals were detected in cells expressing RING-SH2^Drk (I, I′ and arrowhead J) and D-CblL (K, K′ and arrowhead in L) than that detected in wild-type follicle cells (G, G′ and arrow in H). (M–R) The colocalization signal of HRP and Hrs were shown in the wild-type (M, M′ and arrow in N), or in cells expressing RING-SH2^Drk (O, O′ and arrowhead in P), and in cells expressing D-CblL (Q, Q′ and arrowhead in R).