Table 1.

Oncogenes and inactive tumor suppressors and the G₁ phase Cdk they may deregulate to signal centrosome amplification.

Genetic alteration	Deregulated Cdk	Reference
Oncogenes
Cyclin D1	Cdk2, Cdk4	[141,142]
ErbB2	Cdk4	[139]
Ras	Cdk4	[22,140]
Tumor Suppressors
E2F3a/b	Cdk2	[33]
MEK2	Cdk4, Cdk6	[136]
p16INK4A	Cdk4, Cdk6	[143,145]
p21Waf1/CIP1	Cdk2, Cdk4	[118,119,121,122]
p53	Cdk2, Cdk4	[86,120,121]
Skp2	Cdk2	[125]
Rb	Cdk2	[82]