Table 1.

Comparison of Biobanks and Phenotypes Across the eMERGE sites

Site	Biobank design	Biobank size and demographics	Phenotypic outcomes
Marshfield	Population-based	20,000; 98% Caucasian, mean age 48, range 18-102	Low HDL cholesterol, cataract (n = 3968) Secondary: diabetic retinopathy
Mayo Clinic	PAD cases identified from the Mayo non-invasive vascular laboratory database; control subjects without PAD identified from the Cardiovascular Health Clinic	1687 cases (mean age 65) and 1725 controls (mean age 60)	Peripheral arterial disease (PAD) (n = 3412); Secondary: red blood cell indices
Northwestern	Outpatient clinic and hospital-based	Approximately 10,000; 12% African American, 8% Hispanic; Mean age 50, range 18 - 90+	Primary: type II diabetes (n = 3531); Secondary: lipids and height
Group Health	ACT Study Cohort of aged 65 and olderrandomly sampled from an HMO all known not to be demented at enrollment and followed for development of dementia, and Alzheimer's Disease (source of cases and controls) ADPR: Alzheimer's disease cases from a model incidence case registry (source of cases)	Approximately 4000 persons over age 65 from ACT Study	Alzheimer Disease (n = 3390), carotid artery stenosis; Secondary: statin adverse events
Vanderbilt	Use of discarded blood/non-human subjects linked to electronic medical records	Approximately 75,000; 70% Caucasian, 10% African American; mean age 53, range 18-100	Electrocardiographic QRS duration (n = 3192); Secondary: PheWAS