Table 1.
Characteristics of patients at baseline
| Qualitative variable - N (%) | NNRTI group N = 671 |
NRTI group N = 225 |
P |
|---|---|---|---|
| Gender [Male] | 536 (79.9%) | 182 (80.9%) | 0.7429 |
| Risk factor for HIV acquisition | 0.6749 | ||
| IVDU | 148 (22.1%) | 46 (20.4%) | |
| Homo-bisexual | 198 (29.5%) | 65 (28.4%) | |
| Heterosexual | 254 (37.9%) | 83 (36.9%) | |
| Other | 16 (2.4%) | 9 (4%) | |
| Unknown | 55 (8.2%) | 22 (9.8%) | |
| Nationality | 0.6511 | ||
| Europe or North America | 608 (90.6%) | 208 (92.4%) | |
| Other | 41 | 12 | |
| Unknown | 22 | 5 | |
| HCV-Ab | 0.8498 | ||
| Positive | 169 (25.2%) | 55 (24.5%) | |
| Negative | 432 (64.4%) | 149 (66.2%) | |
| Unknown | 70 (10.4%) | 21 (9.3%) | |
| CDC '93 Class C | 200 (29.8%) | 64 (28.4%) | 0.6982 |
| CD4+ classes | 0.0782 | ||
| ≥ 200/mm3 | 342 (51.0%) | 93 (41.3%) | |
| 201-350/mm3 | 146 (21.8%) | 56 (24.9%) | |
| 351-500/mm3 | 101 (15.0%) | 45 (20.0%) | |
| > 500/mm3 | 82 (12.2%) | 31 (13.8%) | |
| Centre | 0.1448 | ||
| Master | 399 (59.5%) | 115 (51.1%) | |
| Chelsea & Westminster | 97 (14.5%) | 38 (16.9%) | |
| ICONA | 139 (20.7%) | 60 (26.7%) | |
| HSR+Modena | 35 (5.3%) | 12 (5.3%) | |
| Calendar year at study initiation | 0.0137 | ||
| 1997-2000 | 264 (39.3%) | 70 (31.1%) | |
| 2001-2003 | 309 (46.1%) | 129 (57.3%) | |
| 2004-2006 | 98 (14.6%) | 26 (11.6%) | |
| Boosted-PI as first line | 78 (11.6%) | 30 (13.3%) | 0.4957 |
| Quantitative variables | |||
| Mean (SD) age [years] | 39 (35-45) | 38 (34-44) | 0.3680 |
| Mean (SD) pre-treatment HIV-RNA [log10 copies/ml] | 5.012 (4.415-5.430) | 5.000 (4.511-5.519) | 0.6269 |
| Median (IQR) CD4-count [cells/mm3] | 196 (86-377) | 249 (103-403) | 0.0234 |