Table 2.
Characteristics of the hinges in the trends of CD4+ T-cell counts (two-phase linear regression model)
| NNRTI group N = 436/627 (69.4%) | NRTI group N = 145/217 (66.8%) | ||||
|---|---|---|---|---|---|
| Time of the hinge relative to the switch (categories) | |||||
| Before the switch | ≤ 180 days from the switch | >180 days from the switch | Before the switch | ≤ 180 days from the switch | >180 days from the switch |
| N = 325/436 (74.5%) | N = 31/436 (7.1%) | N = 80/436 (18.3%) | N = 118/145 (81.4%) | N = 9/145 (6.2%) | N = 18/145 (12.4%) |
| Increasing CD4+ trend after the hinge relative to the pre-switch trend (categories) | |||||
| N = 210/325 (64.6%) | N = 7/31 (22.6%) | N = 18/80 (18.7%) | N = 68/145 (46.9%) | N = 3/9 (33.3%) | N = 1/18 (5.5%) |
| Estimates of the increasing trend (median CD4+/mm3/day, IQR or min-max*/individual$ values where indicated) | |||||
| 1.0003 | 1.0003 | 1.0005 | 1.0003 | *min-max: | |
| 1.0002 to 1.0005 | 1.0002 to 1.0082 | 1.0001 to 1.0015 | 1.0002 to 1.0004 | 1.0001 to 1.00025 | $1.0001 |
| Stationary CD4+ trend after the hinge relative to the pre-switch trend (categories) | |||||
| N = 68/325 (20.9%) | N = 8/31 (25.8%) | N = 20/80 (25%) | N = 32/145 (22.1%) | N = 3/9 (33.3%) | N = 5/18 (27.8%) |
| Decreasing CD4+ trend after the hinge relative to the pre-switch trend (categories) | |||||
| N = 47/325 (14.5%) | N = 16/31 (51.6%) | N = 45/80 (56.2%) | N = 18/145 (12.4%) | N = 3/9 (33.3%) | |
| N = 12/18 (66.7%) | |||||
| Estimates of the decreasing trend (median CD4+/mm3/day, IQR or min-max* values where indicated) | |||||
| -1.0002 | -0.99981 | -1.0007 | -1.0003 | *min-max: | -1.0004 |
| -1.0001 to -1.0004 | -0.99959 to -0.999945 | -1.0029 to 1.0003 | -1.0005 to -1.0002 | -0.99585 to -0.99988 | -1.0015 to -1.0003 |