Table 2.
Correlation of SOX2 score and clinicopathological parameters
| SOX2 | ||||
|---|---|---|---|---|
| N total | Negative Score 0 | Positive Score 1-3 | p-value | |
| Tumor size | ||||
| pT1 | 59 | 46 (78%) | 13 (22%) | 0.073 |
| pT2 to pT4 | 27 | 16 (59%) | 11 (41%) | |
| Nodal status | ||||
| Node-negative | 62 | 44 (71%) | 18 (29%) | 0.789 |
| Node-positive | 23 | 17 (74%) | 6 (26%) | |
| Histology | ||||
| Ductal | 76 | 49 (73%) | 18 (27%) | |
| Lobular | 11 | 10 (91%) | 1 (10%) | 0.053 |
| Others | 8 | 5 (38%) | 5 (63%) | |
| Grading | ||||
| I-II | 60 | 45 (75%) | 15 (25%) | 0.361 |
| III | 26 | 17 (65%) | 9 (35%) | |
| Lymphovasc. inv. | ||||
| Negative | 63 | 48 (76%) | 15 (24%) | 0.161 |
| Positive | 23 | 14 (61%) | 9 (39%) | |
| ER status | ||||
| Negative | 17 | 12 (71%) | 5 (29%) | 0.877 |
| Positive | 69 | 50 (73%) | 19 (28%) | |
| PR status | ||||
| Negative | 22 | 16 (73%) | 6 (27%) | 0.939 |
| Positive | 64 | 46 (72%) | 18 (28%) | |
| HER2 | ||||
| Negative | 75 | 55 (73%) | 20 (27%) | 0.503 |
| Positive | 11 | 7 (64%) | 4 (36%) | |
| Subtype | ||||
| Luminal A/B * | 73 | 53 (73%) | 20 (27%) | |
| HER2 subtype | 6 | 4 (67%) | 2 (33%) | 0.952 |
| Triple negative | 7 | 5 (71%) | 2 (29%) | |
*Luminal A tumors are defined as tumors with expression of one or both hormone receptors without overexpression of Her2; Luminal B tumors express one or both hormone receptors and show also Her2 overexpression.