Table 2.

Outcome measures for clinical trials in juvenile idiopathic arthritis validated by the American College of Rheumatology26

Active joint count (joints with swelling or tender/pain on motion and limitation of motion) Joints with limited range of motion Parent/patient global assessment (measured on a 0–10 VAS) Physician global assessment (measured on a 0–10 VAS) Laboratory measure of inflammation (erythrocyte sedimentation rate, C-reactive protein) Functional assessment (Childhood Health Assessment Questionnaire)

Notes: ACR Pediatric 30 response: A patient is considered to have responded if there has been an improvement in at least three variables by at least 30% and worsening in not more than one variable by more than 30%. Flare: A patient is considered to flare if there has been worsening of 30% or more in at least three of the six variables and at least 30% improvement in no more than one variable. A minimum change of 20 mm in global assessment and at least two additional active joints is necessary.

Abbreviation: VAS, visual analog scale.