Figure 1.

Acute-phase assessments. Measures of acute response in the modified conjunctival allergen challenge assay. A) Mean values of summated symptom scores for five treatment groups. Symptoms include tearing, lid edema, conjunctival chemosis, and conjunctival redness. All treatment groups are significantly different from untreated (NS/NC, P > 0.001). B) Mast cell counts from three consecutive conjunctival tissue sections observed under a 200× field microscope. No significant differences were observed between groups. Error bars indicate standard error in both (A and B).

Abbreviations: NS/NC, no sensitization, no challenge (naïve animals); S/C, sensitized, challenged; vehicle, sensitized, challenged, drug vehicle only; olopatadine, sensitized, challenged, 0.1% topical olopatadine; alcaftadine, sensitized, challenged, 0.025% topical alcaftadine.