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mtDNA from AS1 cells is damaged. Equal amounts of total genomic DNA from control (c) and AS1 (AS1) cells was digested with PvuII and separated on a 0.5% agarose gel under native or denaturing conditions (see Materials and Methods). (A and D) Genomic DNA digested with PvuII hybridized to a total genomic DNA probe. (B and E) Genomic DNA digested with PvuII and hybridized with a mtDNA probe. (C and F) Genomic DNA digested with SacI and hybridized to a mtDNA probe.
