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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Eur J Neurosci. 2010 Dec 29;33(4):736–747. doi: 10.1111/j.1460-9568.2010.07553.x

Figure 6. Corticolimbic circuits impacted by metabotropic glutamate receptor blockade induced by LY341495 microinjectionin NAc shell.

Figure 6

Close-up of glutamatergic (green) and GABAergic (red) neurotransmission under normal conditions and in the presence of LY341495 (LY, blue), which blocks presynaptic mglu2/3 receptors and consequently enhances release of both glutamate and GABA from their respective neurons (insets). Glutamatergic inputs (green) are shown from medial prefrontal cortex, orbitofrontal cortex, hippocampus, thalamus, and basolateral amygdale. GABAergic medium spiny neurons (deep red) and GABAergic inputs (red) to NAc shell are shown from ventral pallidum and ventral tegmental area. Dopaminergic inputs are shown from the ventral tegmental area (black). Circuit diagram is modified from Faure et al., 2010, with inset based on Swanson et al., 2005.