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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Virology. 2011 Jan 12;411(1):32–40. doi: 10.1016/j.virol.2010.12.029

Fig. 1. MVCres HIV-1 infection in the presence of MVC is inefficient at low CCR5 density.

Fig. 1

HIV-1 reporter virus pseudotyped with the Env of MVCsens HIV-1 (a) or MVCres HIV-1 (b) were used to infect JC clones with same CD4 but different CCR5 densities, in the presence of varying MVC concentrations. Left panels: Infectivity was determined by measuring luciferase activity in cell lysates on day 3 after infection. In control experiments using uninfected cells or infected cells treated with 10 μM T-20 (a fully inhibitory concentration) luciferase activities ranged between 20 and 40 RLU (not shown). Right panels: Infectivity data in each cell clone were normalized to infectivity values obtained in the absence of drug and percentages of MVC inhibition determined (right panels). Data points are mean ± S.D. of at least 2 replicates and are from one representative experiment of three.