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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Dev Biol. 2010 Dec 11;351(1):186–198. doi: 10.1016/j.ydbio.2010.12.008

Figure 8. The source of Neur for the endocytosis of Delta and the Delta-bound extracellular domain of Notch is outside of the lineage.

Figure 8

Embryos are stained with Eve, anterior end is up, and midline is marked by vertical lines. Panel A: Wild type, rarely a sib is visible in a 14 hr old embryo with weak Eve expression. Panel B: cyclin a mutant embryo, the GMC-1 fails to divide, and it adopts an RP2 identity. Panel C: a numb mutant embryo, both daughter cells of a GMC-1 adopts a sib fate. The penetrance of this phenotype is partial (see text). Panel D: numb;cyc a double mutant embryo, the numb phenotype in terms of the fate specification, is epistatic to the cyc a phenotype (cell division defect of cyc a is unaffected in the double mutant and this is expected since Numb is not required for cell division).