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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Trends Immunol. 2011 Feb 1;32(2):50–56. doi: 10.1016/j.it.2010.12.004

Table I.

Multiple gene deficiency models give rise to innate CD8+ T cells

Gene deficiency or transgenic model Eomes expression in CD8 SP thymocytes Cell extrinsic effect Role of IL-4 Role of NKT lineage cells References
Itk−/− elevated yes Increased IL-4R
Hyper IgE
Dependent on IL-4		 Increase γδ NKT
Dependent on PLZF and SAP		 [10–12, 16, 21]
Klf2fl/fl
Cd4Cre 		elevated yes Increased IL-4R
Hyper IgE
Dependent on IL-4		 Increased αβ & γδ NKT
Dependent on PLZF		 [16, 17]
Cbpfl/fl
LckCre 		elevated yes Increased IL-4R n.d. [16, 18]
SLP76:Y145F elevated n.d.a n.d. n.d. [20, 22]
Id3−/− elevated yes Increased IL-4R
Hyper IgE
Dependent on IL-4		 Increased αβ and γδ NKT
Dependent on PLZF and SAP		 [19, 22–25]
CIITAtg elevated yes STAT6 dependent Increased PLZF expression in polyclonal CD4+ T cells
Dependent on SAP		 [1, 26–31]
a

not determined