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. Author manuscript; available in PMC: 2012 Feb 1.

Published in final edited form as: Hear Res. 2010 Nov 10;272(1-2):42–48. doi: 10.1016/j.heares.2010.11.002

Average ABR thresholds at two ages for (A) Coch^−/− and (B) Coch^G88E/G88E mouse models. At 13 months of age, the Coch^−/− mice (n=6) showed no significant elevation of ABR thresholds in comparison to the Coch^+/+ (n=5) and Coch^−/+ (n=6) littermates. At 21 months, Coch^−/− mice (n= 11) showed elevated ABR thresholds or absent ABRs at the highest frequency tested as compared to Coch^+/+ (n=9) and Coch^−/+ (n=12) littermates, with 9 of 11 Coch^−/− mice showing absent ABRs at 41.2 kHz. In the Coch^G88E/G88E mouse model, ABR thresholds were elevated for all frequencies at 21 months of age, with 4 of 8 showing absent ABR. In contrast to Coch^−/+ mice, Coch^G88E/+ mice show ABR threshold elevations similar to those of the Coch^G88E/G88E mice. Error bars represent standard error. [Color figure can be viewed in the online issue, which is available at http://www.sciencedirect.com/science/journal/03785955.]

Average ABR thresholds at two ages for (A) Coch^−/− and (B) Coch^G88E/G88E mouse models. At 13 months of age, the Coch^−/− mice (n=6) showed no significant elevation of ABR thresholds in comparison to the Coch^+/+ (n=5) and Coch^−/+ (n=6) littermates. At 21 months, Coch^−/− mice (n= 11) showed elevated ABR thresholds or absent ABRs at the highest frequency tested as compared to Coch^+/+ (n=9) and Coch^−/+ (n=12) littermates, with 9 of 11 Coch^−/− mice showing absent ABRs at 41.2 kHz. In the Coch^G88E/G88E mouse model, ABR thresholds were elevated for all frequencies at 21 months of age, with 4 of 8 showing absent ABR. In contrast to Coch^−/+ mice, Coch^G88E/+ mice show ABR threshold elevations similar to those of the Coch^G88E/G88E mice. Error bars represent standard error. [Color figure can be viewed in the online issue, which is available at http://www.sciencedirect.com/science/journal/03785955.]