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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Neurobiol Dis. 2010 Dec 17;42(1):21–34. doi: 10.1016/j.nbd.2010.12.010

Figure 1.

Figure 1

CD47 ablation improves functional outcome after moderate contusion. (A) Repeated measures ANOVA with fixed effects and Bonferroni posthoc t tests revealed a significant improvement in locomotor recovery by day 7 in CD47−/− mice (n=18, ■) relative to wildtype (n=19, ♦) as assessed by the BMS (*** p < 0.001). (B) Subscore analysis revealed a similar improvement in hindlimb coordination after day 14. Means ± standard error include data from two independent experiments. (C) Six weeks post-SCI, CD47−/− (n=18) mice walk at higher overall speeds than WT (n=19) as assessed by TreadScan analysis (* p < 0.05). (D) The epicenters of contused CD47−/− mice exhibit more white matter than WT as determined via Eriochrome cyanine staining (images converted to monochrome) (E) Eriochrome cyanine staining of serial coronal sections throughout the contusion revealed significantly more white matter at the epicenters of CD47−/− cords (n=18) relative to WT (n=19) six weeks post injury. Data are means ± SEM. (** p < 0.01).