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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Neurobiol Dis. 2010 Dec 17;42(1):21–34. doi: 10.1016/j.nbd.2010.12.010

Figure 10.

Figure 10

CD47 expression on CNS-derived ECs, but not on host neutrophils, appears to facilitate neutrophil diapedesis. MVs isolated from CD47−/− cortex and implanted into either WT (B) or CD47−/− (D) hosts inosculate with host vasculature and exhibit pronounced luminal adhesion of LEA-stained (green) hematopoietic cells, suggesting a defect in MV extravasation of neutrophils (B,D; red, arrows). WT MVs exhibit no luminal adhesion of neutrophils from either host (A,C; arrows). Under these conditions, matrigel alone did not significantly promote mature WT host MV invasion into the subcutaneously engrafted plug (E, inset in A); LEA (green), PMN clone 7/4 (red), Hoechst (blue). Images are representative of 3 independent experiments.