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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Neurobiol Dis. 2010 Dec 17;42(1):21–34. doi: 10.1016/j.nbd.2010.12.010

Figure 9.

Figure 9

CD47 ablation decreases neutrophil extravasation and myeloperoxidase activity in the contusion epicenter. (A–C) Knockout of CD47 (n=5) leads to significantly fewer neutrophils within the injury epicenter and penumbra both 1 day (* p < 0.05) and 3 days (*** p < 0.001) post injury (d.p.i.) relative to WT (n=4) [PMN clone 7/4 (red), LEA (green), GFAP (blue)]. Ablation of the CD47 ligand TSP-1 (n=5) failed to change levels of neutrophil extravasation 3 d.p.i. As no significant behavioral or extravasation effects were observed at 3 d.p.i., TSP-1−/− mice were not assessed at 1 d.p.i. All images were taken with a 4× objective. Data are means ± SEM. (D) CD47 ablation (n=5) reduces epicenter myeloperoxidase activity (mU MPO activity/mg total protein) 3 d.p.i. relative to WT (n=4). Data are means ± SEM (** p < 0.01).