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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2011 Jan 9;17(3):309–318. doi: 10.1016/j.bbmt.2010.12.710

Fig. 4. The effect of Ag-specific iTregs on expansion and infiltration of Teffs.

Fig. 4

Lethally irradiated OVA+ (B6 × bm12)F1 mice were transplanted with B6 TCD-BM plus 0.5 × 106/mouse Teffs (CD4+CD25−) isolated from Luc-Tg mice on B6 background. One group of recipients was also transferred with additional 0.25 × 106/mouse OT-II iTregs (CD4+CD25+GFP+). Donor Teffs were monitored in recipient mice 17 and 28 days after BMT. A, animals were imaged from the ventral position for quantification of donor T cells. B, the average of relative signal intensity of 4 mice per group, and the data represent one of 2 replicate experiments.