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. Author manuscript; available in PMC: 2012 Feb 20.
Published in final edited form as: Mol Cell Endocrinol. 2010 Dec 30;333(2):160–171. doi: 10.1016/j.mce.2010.12.028

Figure 7. Hyperglycemia induced oxidative stress in HSCs by elevating the level of ROS and LPO, which was attenuated by curcumin, likely by increasing the contents of GSH.

Figure 7

Passaged HSCs were cultured in media with glucose at 100 mg/dl, or 450 mg/dl in the presence of curcumin (0–30 μM) for 24 hr. Levels of intracellular ROS (A), LPO (B) and GSH (C), as well as the ratio of GSH/GSSG (D) were analyzed. Values were represented as means ± S. D. (n=6). *p<0.05 vs cells cultured in media with glucose at 100 mg/dl. ‡p<0.05 vs cells stimulated with glucose at 450 mg/dl alone.