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. Author manuscript; available in PMC: 2011 Feb 15.
Published in final edited form as: Mol Immunol. 2010 Nov–Dec;48(1-3):59–72. doi: 10.1016/j.molimm.2010.09.012

Fig. 1.

Fig. 1

Amino acid sequence alignment of anti-Aβ VH (A) and VL (V-KAPPA) (B) domains with the closest germline V, D and J genes identified using IMGT/V-QUEST for the nucleotide sequences and IMGT/DomainGapAlign2 for the amino acid sequences (Yousfi Monod et al., 2004; Lefranc et al., 2009). Numbering and CDR definition are according to the IMGT unique numbering (Lefranc et al., 2003). Dashes indicate identical amino acids, whereas dots indicate no amino acids at the corresponding IMGT numbering positions. Residues contacting the antigen are underlined. (#) The conserved amino acids Q14>K; F35>S; A70>S; K84>R; A92>T; N93>S; I107>R, compared to IGHV8-8*01 suggest the existence of a new IGHV8-8 gene not yet sequenced in BALB/c mice.