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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: J Immunol. 2011 Jan 5;186(3):1512–1520. doi: 10.4049/jimmunol.1002373

FIGURE 9. Effect of CD1d deficiency on self vs. non-self antibody responses in autoimmune-prone mice.

FIGURE 9

A,Spleen cells from CD1d−/− BWF1 mice or control littermates (10-mo-old) were cultured with or without LPS. Supernatants collected on day 5 were assayed for autoantibodies and total IgG. B, CD1d−/− BWF1 mice and control littermates (10-wk-old) were immunized with a self (p31) or a foreign (p106) peptide, in CFA and challenged with the peptide in IFA, as described in Methods. Sera collected on day 14 post-challenge were assayed for IgG anti-peptide Abs. Results are shown as the mean ± SD of the mean triplicate O.D. from 6 mice per group (*p <0.05). Results are from one representative of two independent experiments.