Skip to main content
. Author manuscript; available in PMC: 2011 Feb 15.
Published in final edited form as: Endocr Relat Cancer. 2010 Aug 16;17(3):R233–R244. doi: 10.1677/ERC-10-0082

Table 3.

Proposed mechanisms of TKI induced hypothyroidism

  • Decrease in enteric thyroid hormone absorption

  • Increased hepatic metabolism of T4 and T3

  • Inhibition of T4 deiodination

  • Impaired iodide update

  • Stimulation of T4 and T3 clearance

  • Destructive thyroiditis

  • Direct inhibition of thyroid peroxidase activity

  • Capillary regression induced by VEGF inhibition

  • Interference with thyroid hormone action at the pituitary gland level