TABLE 1.
Clinical characteristics of subjects
| COPD | Controls | p-value | |
|---|---|---|---|
| Age yrs | 65±7 | 65±7 | ns |
| Males:females n | 12 : 6 | 9 : 7 | ns |
| BMI kg·m−2 | 24.5±4.7 | 25.7±4.8 | ns |
| Fat free mass index | 15.8±2.3 | 17.4±2.5 | ns |
| FEV1 L | 0.93±0.40 | 3.03±0.63 | <0.0001 |
| FEV1 % pred | 35±15 | 112±13 | <0.0001 |
| DL,CO % pred | 37.9±14.3 | 91.3±16.1 | <0.0001 |
| TLC % pred | 120±19 | 108±11 | 0.03 |
| RV % pred | 193±51 | 103±16 | <0.0001 |
| Quadriceps MVC kg | 29.8±8.6 | 37.7±9.8 | 0.02 |
| MVC/BMI | 1.2±0.3 | 1.5±0.5 | 0.04 |
| Quadriceps endurance# s | 91±47 | 127±72 | ns |
| 6MWD m | 362±145 | 630±86 | <0.0001 |
| SGRQ total score | 57±11 | 3±4 | <0.0001 |
| Locomotion time min | 48±45 | 106±53 | 0.004 |
Data are presented as mean± sd, unless otherwise stated. COPD: chronic obstructive pulmonary disease; BMI: body mass index; FEV1: forced expiratory volume in 1 s; %pred.: % predicted; DL,co: carbon monoxide diffusion capacity; TLC: total lung capacity; RV: residual volume; MVC: maximal voluntary contraction; 6MWD: 6-min walk distance; SGRQ: St George's Respiratory Questionnaire, ns: nonsignificant i.e. p>0.05.
#
defined as the time for force to fall to 80% of baseline.