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. 2010 Dec 1;2010:108190. doi: 10.1155/2010/108190

Table 1.

Selective vulnerability of synaptic connections between entorhinal layer II neurons and their targets in the hippocampus across different species during aging and in models relevant to Alzheimer's disease. In this table, “cognitive aging” refers to studies where correlations with memory deficits were observed in aged populations, while “aging” refers to studies comparing across different time points without behavioral assessment. PP: perforant path; DG: dentate gyrus; APP: amyloid precursor protein.

Species Nature of deficit Vulnerable synapses Reference
Human Cognitive aging PP > DG/CA3 [1]
Monkey Aging PP > DG [63]
Dog Aging PP > DG [64]
Rat Cognitive aging PP > CA3 [54]
Mouse Aging PP > DG [61]
Mouse APP mutation (Tg2576) PP > DG [65]
Mouse APP mutation (PDAPP) PP > DG [58]