Table 2.

Summary of results from association studies in AF cohorts

Gene	Polymorphism	Cases	Controls	Ethnicity	Comment	P-value	Odds ratio	References
KCNE1 minK	38G	331	441	Caucasian		0.004	1.73	32
KCNE1 minK	38G	108	108	Asian		0.024	1.80	34
KCNE5	97T	158	96	Caucasian		0.007	0.52	35
KCNH2	K897T	1207	2475	Caucasian		0.00033	1.25	33
GNB3	C825T	291	292	Caucasian		0.02	0.46	36
eNOS	2786C	331	441	Caucasian		0.01	1.50	32
eNOS	G894T	51	289	Caucasian	HF patients	0.001	3.2	127
SCN5A	H558R	157	314	Caucasian		0.002	1.6	31
GJA5	–44AA/+71GG	173	232	Asian		<0.006	1.514	37
AGT	M235T	250	250	Asian		<0.001	2.5	39
AGT	G-6A	250	250	Asian		0.005	3.3	39
AGT	G-217A	250	250	Asian		0.002	2.0	39
AGT	T174M	968	8267	Caucasian		0.05	1.2	126
AGT	20C/C	968	8267	Caucasian		0.01	1.5	126
ACE	D/D	51	289	Caucasian	HF patients	0.016	1.5	127
ACE	D/D	404	520	Caucasian		<0.001	1.89	128
MMP2	C1306T	196	873	Asian		1.26 × 10−2	8.1	129
IL10	A-592C	196	873	Asian		3.7 × 10−3	0.32	129
IL6	G-174C	26	84	Caucasian	Post-operative AF (after CABG)	<0.001	3.25	130
SLN	C-65G	147	92	Caucasian		0.011	1.98	124

ACE, angiotensin-converting enzyme; AGT, angiotensinogen; CABG, coronary artery bypass graft surgery; eNOS, endothelial nitric oxide synthase 3; GNB3, guanine nucleotide-binding protein; GJA5, connexin 40; HF, heart failure; IL6, interleukin 6; IL10, interleukin 10; MMP, matrix metalloproteinase; SLN, sarcolipin gene.