Table 1.
Characteristics of the study samples
| ARIC | CHS | FHS | RS | AGES | WGHS | |
|---|---|---|---|---|---|---|
| Cohort information | discovery | replication | ||||
| Study Desiagn | prospective multi-center | Population-based prospective multi-center | Community-based family multi-generation | Population-based prospective | Population-based prospective | Trial |
| Analyzed sample size, CKD/eGFRcrea/eGFRcys | 8069 / 6525 / 6430 | 3278 / 3278 / 2844 | 4140 / 3934 / 2992 | 4390 / 4390 / NA | 3219 / 3219 / NA | 18247 / 18247 / NA |
| Sample characteristics* | mean (SD) / % (n) | mean (SD) / % (n) | mean (SD) / % (n) | mean (SD) / % (n) | mean (SD) / % (n) | mean (SD) / % (n) |
| Age, years | 63.1 (5.6) | 72.4 (5.4) | 62.4 (11.6) | 70.0 (9.0) | 76.4 (5.5) | 54.7 (7.1) |
| Male | 46.7 (3047) | 39.2 (1286) | 45.5 (1890) | 38.6 (1694) | 42 (1352) | 0 |
| Hypertension prevalence | 43.0 (2793) | 52.4 (1719) | 57.4 (2377) | 34.1 (1497) | 81 (2596) | 24.4 (4460) |
| Diabetes mellitus | 13.7 (893) | 11.8 (385) | 9.8 (406) | 10.7 (470) | 11.5 (368) | 2.6 (474) |
| eGFR cystatin, ml/min/1.73m2 | 84.1 (19.7) | 79.9 (18.3) | 77.9 (16.9) | NA | NA | NA |
| eGFR creatinine, ml/min/1.73m2 | 80.6 (17.2) | 80.0 (22.6) | 85.2 (23.5) | 77.1 (17.2) | 73.0 (20) | 90.4 (22.8) |
| CKD, eGFR<60 ml/min/1.73m2 | 9.1 (731) | 18.7 (612) | 10.7 (445) | 13.7 (600) | 24.3 (781) | 6.3 (1151) |
*
Information on demographics, hypertension, and diabetes are ascertained at the visit eGFRcrea was measured. Sample sizes for CKD and eGFRcrea in ARIC and FHS differ as these studies use a cumulative definition of CKD as detailed in the method section.
Abbreviations: ARIC: Atherosclerosis Risk in Communities Study, CHS: Cardiovascular Health Study, FHS: Framingham Heart Study, RS: Rotterdam Study, AGES: Age Gene/Environment Susceptibility-Reykjavik Study, WGHS: Women’s Genome Health Study, SD: standard deviation, CKD: chronic kidney disease, eGFR: estimated glomerular filtration rate.